Is found in Mortierella sp.Fungus by screening for antioxidants (indophenol reducing) together with its acid, glycine and its methyl ester form. DPPH Radical scavenging activity of 2,4,5-trimethylresorcinol was 17,7 μM ED50 , compared to α-tocopherol 27and BHT 37 μM ; inhibitory activity toward Linoleate Auto-Oxidation in an Emulsion System was 62,7% compared to α-tocopherol 27,1 and BHT 81,0%.It is also calmodulin-dependent phosphodiesterase inhibitor KS-506
These compounds are naturally occurring in medicinal mushroom Maitake – Grifola Confluens and are described as cholesterol lowering agents (USPatent 5859067, 1999, treatment of cardiovascular desease). Maitake and its extracts are widely used as potentiators of human immune system and for other purposes.
These compounds are also described as inhibitors of H-SCH 23390 binding to dopamine D1 receptorsubfamily in rat striatal brain membranes, extracted from edible mushroom Albatrellus ovinus (1996).
There is numerous literature describing synthesis of grifolin and neogrifolin from 5-methylresorcinol. These synthesis are difficult and new approaches should be found.